基本信息:贾闻青,药学博士,毕业于天津医科大学。主要从事分子靶向药物的发现和作用机理研究。近年来,发表SCI论文共12篇,其中以第一作者发表SCI论文6篇,申请国家发明专利3项,授权国家发明专利1项。主讲《药剂学及实验》等课程。
研究方向
1.分子靶向药物的筛选
2.药物的作用机理研究
3.药物设计
发表论文
1.Jia WQ, Luo SY, Guo H, et al. Development of PI3Kα inhibitors for tumor therapy [J]. J Biomol Struct Dyn, 2023, 41(17):8587-8604.
2.Jia WQ, Luo SY, Zhao WN, et al.Discovery of Novel PI3Kδ Inhibitors Based on the p110δ Crystal Structure [J]. Molecules, 2022,27(19), 6211.
3.Jia WQ, Liu YY, Feng XY et al. Discovery of novel and highly selective PI3Kδinhibitors based on the p110δ crystal structure[J]. J Biomol Struct Dyn, 2020, 38(8): 2499-2508.
4.Jia WQ, Feng XY, Liu YY et al. Identification of phosphoinositide-3 kinases delta and gamma dual inhibitors based on the PI3Kδ/γ crystal structure[J]. Lett Drug Des Discov, 2020.
5.Feng XY, Jia WQ (co-first author), Liu X, et al. Identification of novel PPARalpha/gamma dual agonists by pharmacophore screening, docking analysis, ADMET prediction and molecular dynamics simulations[J]. Comput Biol Chem, 2019, 78: 178-189.
6.Jia WQ, Jing Z, Liu X, et al. Virtual identification of novel PPARalpha/gamma dual agonists by scaffold hopping of saroglitazar[J]. J Biomol Struct Dyn, 2018, 36(13): 3496-3512.
专利
一种高吗啉类化合物、制备方法、药物组合物及应用,CN114149418A.
奖励
1.苏州工业园区奖学金2022.12
2.校级优秀研究生干部2021.10
3.国家奖学金2018.11
4.山东省优秀毕业生2016.5